Born in Japan, raised in Nebraska and schooled in Chicago at Roosevelt University, Dandridge began her acting career with leading roles on Broadway in Spamalot (Lady of the Lake), Rent (Joanne), Aida (Aida), Tarzan(Kala) and Jesus Christ Superstar (Soul Girl, Disciple). Most recently, she played the role of Papa Ge, the sly demon of death, in the Tony Award-winning Broadway revival of Ahrens and Flaherrty's "Once on This Island", for which she received a Grammy Award nomination for Best Musical Theater Album. Dandridge is the first woman to ever play this role, completely reinventing the character with her fearless portrayal. She has toured the U.S. and Europe six times and has been featured in several regional theatre productions (including multiple stints at The Geffen Playhouse and Pasadena Playhouse). She has also performed at The Hollywood Bowl and at Royal Albert Hall in London.

Dandridge has voiced several videogame characters and worked alongside Neil Druckmann in “Uncharted 4: A Thief’s End” and starred as Marlene in “The Last Of Us” for which she will reprise her role in the highly-anticipated HBO adaptation. She has also voiced various characters in “Dota 2”, Alyx Vance in “Half-Life 2”, and Katherine Collins in the Award-winning independent video game “Everybody’s Gone To The Rapture” for which she won the 2016 BAFTA for “Best Performer”.

In her Nebraska hometown, Merle has been inducted into the Hall of Fame where she spends time giving workshops, speeches, performances and participating in projects to raise arts awareness for the school district she grew up in. In Los Angeles, where she currently resides, she serves on the Board of Directors and co-chairs the DEI Committee of The Geffen Playhouse. She also lends her voice, support, and serves as a mentor at Harvest Home LA which provides housing and holistic support to homeless pregnant woman.